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Primary links

  • Allergy & Asthma
  • Autoimmune Disease
  • Transplantation
  • Type 1 Diabetes
  • Clinical Trial Info
Siplizumab in T1DM (DESIGNATE)
Siplizumab in T1DM (DESIGNATE)
Siplizumab in T1DM (DESIGNATE)
T1D Extended Study (T1DES)
T1D Extended Study (T1DES)
T1D Extended Study (T1DES)
T1D Extended Study (T1DES)
T1D Extended Study (T1DES)
T1D Extended Study (T1DES)
T1D Extended Study (T1DES)
T1D Extended Study (T1DES)
T1D Extended Study (T1DES)
T1D Extended Study (T1DES)
T1D Extended Study (T1DES)

Immune Tolerance and Type 1 Diabetes

Type 1 diabetes (T1D) is a chronic inflammatory disease that develops when the body’s immune system mistakenly attacks the cells that make insulin (called ‘beta cells’).  Insulin allows the body to use energy from food and helps control blood sugar levels, and without it the body cannot function properly. Currently, T1D is treated by life-long insulin replacement, which treats the major symptom but does not cure the underlying disease.

The Immune Tolerance Network (ITN) conducts studies with the goal of identifying treatments that will preserve beta cells and insulin production for individuals recently diagnosed with T1D. 

This page contains a list of ITN's T1D clinical trials that are currently enrolling participants. To see all of ITN's active and completed studies in T1D, please visit For Researchers.

Clinical Trials - Type 1 Diabetes

Active

Siplizumab in T1DM (DESIGNATE)

Principal Investigator:
Stephen Gitelman, MD , University of California San Francisco
DESIGNATE is a clinical study to identify a safe, metabolically favorable, dosing regimen for siplizumab in patients with type 1 diabetes mellitus.
Learn more: Study Summary Clinicaltrials.gov Study Website

T1D Extended Study (T1DES)

Principal Investigator:
Linda DiMeglio, MD, MPH, Indiana University and Riley Hospital for Children, Indianapolis, IN
T1DES is a clinical study for people with type 1 diabetes who were previously enrolled in an ITN clinical study.
Learn more: Study Summary Clinicaltrials.gov Study Website
View All Clinical Trials

The Immune Tolerance Network and is sponsored by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

National Institute of Allergy and Infectious Diseases

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