Data from Immune Tolerance Network (ITN) mechanistic work will be reported at the upcoming American Academy of Allergy, Asthma, and Immunology (AAAAI) meeting on March 2-6 in Orlando, FL.
Two abstracts present data from an ITN pilot study conducted to help design the mechanistic strategy for a larger trial comparing SLIT vs. SCIT immunotherapy in allergic rhinitis:
Interluekin-35 suppresses allergen-specific Th2 response in patients with grass pollen induced seasonal allergic rhinitis (Mohamed Shamji, PhD, Imperial College London)
Effects of nasal allergen challenge on T cell signature in peripheral blood in patients with severe seasonal allergic rhinitis (Mohamed Shamji, PhD, Imperial College London)
A third abstract evaluates the diagnostic value of a functional assay for detecting peanut allergy vs. asymptomatic peanut IgE-sensitivity:
IgE-facilitated peanut-allergen binding to B cells (IgE-FAB peanut): a diagnostic biomarker for peanut allergy? (Mohamed Shamji, PhD, Imperial College London)