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Abstract
GRADUATE is a clinical research trial, which will test whether a novel drug called Dupixent® given with grass pollen immunotherapy will help the immunotherapy work in a shorter treatment period and remain effective after the completion of treatment. Immunotherapy reduces symptoms of hay fever and modifies the allergic disease by increasing tolerance to the grass pollen.
We want to hear from volunteers at any time of year.
Participants in the GRADUATE study will be asked to start treatment a while before the hay fever season begins, and will be randomly assigned to one of three groups who will be given:
- Grazax® plus Dupixent®
- Grazax® plus placebo (an inactive substance made to look like the study drug)
- placebo plus placebo
The total study length is 3 years. The study visits are summarized below:
| Treatment Period | 2 years | Visits every 4 weeks to provide treatment and monitor general health and hayfever symptoms |
| Follow-up Period | 1 year | Monthly phone calls and 5 visits throughout the year to check on progress |
If eligible, participants will receive medical advice about their hay fever and rescue medications (like antihistamines and nasal sprays) in season as needed, as well as compensation for expenses.
About This Study
GRADUATE is a clinical research trial, which will test whether a novel drug called Dupixent® given with grass pollen immunotherapy will help the immunotherapy work in a shorter treatment period and remain effective after the completion of treatment. Immunotherapy reduces symptoms of hay fever and modifies the allergic disease by increasing tolerance to the grass pollen.
We want to hear from volunteers at any time of year.
Participants in the GRADUATE study will be asked to start treatment a while before the hay fever season begins, and will be randomly assigned to one of three groups who will be given:
- Grazax® plus Dupixent®
- Grazax® plus placebo (an inactive substance made to look like the study drug)
- placebo plus placebo
You cannot pick your group. A computer randomly picks who will be in which group. Neither you nor the study team will know your group. After all participants have finished the study, we will tell you which group you were in.
The total study length is 3 years. The study visits are summarized below:
| Treatment Period | 2 years | Visits every 4 weeks to provide treatment and monitor your general health and hayfever symptoms |
| Follow-up Period | 1 year | Monthly phone calls and 5 visits throughout the year to check on progress |
If eligible, you will receive medical advice about your hay fever and rescue medications (like antihistamines and nasal sprays) in season as needed, as well as compensation for your expenses.
Do you Qualify for this Clinical Trial?
If you are between 18 and 65 and have grass pollen allergy, you may be eligible to participate in this London-based clinical study.